![]() ![]() The present work aimed to create chitosan/beta-tricalcium phosphate-based scaffolds coated with silk fibroin and evaluate their potential for bone tissue engineering. Polymeric scaffolds allow the incorporation of bioactive agents that improve their biological and mechanical performance, making them suitable materials for bone regeneration solutions. By introducing scaffolds that can be autografts and/or allografts, tissue engineering provides new approaches to manage the major burdens involved in this process. Laboratory of Ceramic Materials and Composites (CERMAT), Federal University of Santa Catarina (UFSC), 88040-900 Florianópolis, SC, Brazilīone regeneration and natural repair are long-standing processes that can lead to uneven new tissue growth. ICVS/3B's-PT Government Associate Laboratory, Braga, Guimarães, Portugalīiomechanics Engineering Laboratory, University Hospital (HU), Federal University of Santa Catarina (UFSC), 88040-900 Florianópolis, SC, Brazil Interdisciplinary Laboratory for the Development of Nanostructures (LINDEN), Department of Chemical Engineering (EQA), Federal University of Santa Catarina (UFSC), 88040-900 Florianópolis, SC, BrazilģB's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal I'm happy to be part of her journey," Abbot said.Laboratory of Innovation on Additive Manufacturing and Molding (NIMMA), Department of Mechanical Engineering (EMC), Federal University of Santa Catarina (UFSC), 88040-900 Florianópolis, SC, Brazil The work she's doing is really difficult and she's helping us make exciting progress. I'm so interested in tissue engineering and using different cells through a materials science lens."Ībbott, likewise, said Altgold is exactly the kind of student she needs for her research. ![]() Abbott's lab does exactly the kind of work I want to pursue. She is mentored by Claude King III, a Ph.D. "The work now is to prove our concept and refine the methodology we're working on," said Altgold, whose participation in the lab is funded by a Summer Undergraduate Research Fellowship (SURF) from CMU's Undergraduate Research Office. The Abbott Lab is back up and running with modifications as part of CMU’s phased re-opening strategy. While the Abbott Lab was closed as part of CMU’s COVID precautions, Altgold worked remotely, honing her skills reading published literature and helping to prepare research articles for publication. "Combining this method with Abbott's expertise in biomaterials has made the whole project feel in-house, totally CMU," she said. Printing material as a 3D gel is a technique developed by the Feinberg group at CMU. "We're trying to find the exact right pretreatment method for pushing the solution through the nozzle in the 3D printer so it will hold its shape after printing," Altgold said. Researchers need to coerce the proteins to hold the shape they need to print, say, a new ear drum. Silk is hard to work with at the cellular level, Abbot said. Producing silk scaffolds in a lab is nothing new, but finding a way to 3D print the material without blending it with potentially problematic materials will be a breakthrough for regenerative medicine. Altgold is aiding the development of a new method of 3D printing silk proteins to create personalized new tissues for patients needing regenerative medicine.Ī magnified image of the silk scaffold after boiling and processing the silkworm coccoons. But it's what happens to the boiled silk solution next that really makes Abbott smile. "Tahlia's very thorough," Abbott said, noting how important silkworms are to multiple projects in her research lab. She dices discarded silkworm cocoons to boil in a sodium bicarbonate solution and separates out certain proteins for use. Silk can provide this scaffold.īut first the raw material has to be processed. In order for cells to grow, they need a support structure. "Silk is a really incredible biomedical material that's been used for a long time in things like sutures,” said Altgold, a junior majoring in materials science and biomedical engineering.īiomedical engineering Professor Rosalyn Abbott focuses on using silk in tissue engineering. Carnegie Mellon University undergraduate Tahlia Altgold makes biomedical research using silk run more smoothly. ![]()
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